Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was
first documented. However, its continued use is challenged by its poor tolerability, poor …

Despite recent changes in the epidemiology of HIV infection and malaria and major
improvements in their control, these diseases remain two of the most important infectious …

The most accessible points of call for most African populations with respect to primary health
care are traditional health systems that include spiritual, religious, and herbal medicine. This …

While vaccination campaigns are ongoing worldwide, there is still a tremendous medical
need for efficient antivirals against SARS-CoV-2 infection. Among several drug candidates …

Background Therapeutic blood plasma concentrations of anti-malarial drugs are essential
for successful treatment. Pharmacokinetics of pharmaceutical compounds are dependent of …

For several decades, the 4-aminoquinolines chloroquine (CQ) and amodiaquine (AQ) were
considered the most important drugs for the control and eradication of malaria. The success …

Background In all settings, there are challenges associated with safely treating patients with
multimorbidity and polypharmacy. The need to characterise, understand and limit harms …

Advances in antiretroviral therapy have turned HIV into a chronic, manageable disease.
Patients often require treatment for co-morbid conditions as well as HIV, and consequently …

Since there is no vaccine or regulatory approved therapy available for treatment of SARS-
CoV-2 infection, the medical need to prevent the transition of a mild into the severe COVID …

Introduction With new effective treatments for SARS-CoV-2, patient outcomes have greatly
improved. However, new medications bring a risk of drug interactions with other …