Ru (II)/amino acid complexes inhibit the progression of breast cancer cells through multiple mechanism-induced apoptosis

F Mello-Andrade, APM Guedes, WC Pires… - Journal of Inorganic …, 2022 - Elsevier
For some cancer subtypes, such as triple-negative breast cancer, there are no specific
therapies, which leads to a poor prognosis associated with invasion and metastases …

Spiroquinazolinone-induced cytotoxicity and apoptosis in K562 human leukemia cells: alteration in expression levels of Bcl-2 and Bax

M Ghasemian, M Mahdavi, P Zare… - The Journal of …, 2015 - jstage.jst.go.jp
Spiroquinazolinone compounds have been considered as a new series of potent apoptosis-
inducing agents. In this study, anti-proliferative and apoptotic effects of the derivatives from …

Strong in Vitro Cytotoxic Potential of New Ruthenium–Cymene Complexes

S Nikolic, DM Opsenica, V Filipovic… - …, 2015 - ACS Publications
Two p-cymenerutheniumchlorido complexes with thiourea derivative of 7-chloroquinoline
(C1) and pyridine-3-imidazole (C2) were synthesized starting from [(η6-p-cymene) RuCl2] 2 …

Antimicrobial, Antiproliferative and Proapoptotic Activities of Extract, Fractions and Isolated Compounds from the Stem of Erythroxylum caatingae Plowman

JS Aguiar, RO Araújo, MD Rodrigues… - International journal of …, 2012 - mdpi.com
In the study, we have examined the antitumor and antimicrobial activities of the methanol
extract, the fractions, a fraction of total alkaloids and two alkaloids isolated from the stem of …

Anticancer activity and mechanism of bis-pyrimidine based dimetallic Ru (II)(η6-p-cymene) complex in human non-small cell lung cancer via p53-dependent pathway

MZ Bhatti, A Ali, HQ Duong, J Chen… - Journal of inorganic …, 2019 - Elsevier
Non-small cell lung cancer (NSCLC) is the most common cancer worldwide, which is related
with poor prognosis and resistance to chemotherapy. Notably, ruthenium-based complexes …

cis-[RuCl (BzCN)(bipy)(dppe)] PF6 induces anti-angiogenesis and apoptosis by a mechanism of caspase-dependent involving DNA damage, PARP activation, and …

LF Magalhaes, F Mello-Andrade, WC Pires… - Chemico-Biological …, 2017 - Elsevier
Antimetastatic activities, low toxicity to normal cells and high selectivity for tumor cells make
of the ruthenium complexes promising candidates in the search for develop new …

Induction of Cell Cycle Arrest and Apoptosis by Ruthenium Complex cis-(Dichloro)tetramineruthenium(III) Chloride in Human Lung Carcinoma Cells A549

AP de Lima, FC Pereira, CAST Vilanova-Costa… - Biological trace element …, 2012 - Springer
Lung cancer is one of the leading causes of death in the world, and non-small cell lung
carcinoma (NSCLC) accounts for approximately 75–85% of all lung cancers. In the present …

The mechanisms of anticancer activity of nisin peptide on myelogenous leukemia cell line (K562) as a new treatment: inducing apoptosis by changing in the …

F Goudarzi, M Esmaeilzadeh, H Yaghoubi - International Journal of …, 2021 - Springer
Lactococcus lactis is a gram positive bacteria that produces nisin, a polycyclic peptide,
during fermentation process. In recent researches, the anticancer activity of nisin has been …

Methoxyquinoline-diethylenetriamine conjugate as a fluorescent zinc sensor

Y Mikata, A Yamashita, K Kawata, H Konno… - Dalton …, 2011 - pubs.rsc.org
A 6-methoxyquinoline conjugated diethylenetriamine derivative, N, N′′-bis (6-methoxy-2-
quinolylmethyl) diethylenetriamine (6-MeOBQDIEN) has been synthesized and its …

In vitro comparison of the cytotoxic effects of statins on U266 myeloma cell line

H Terzi, A Altun, M Şencan - Indian Journal of Medical Research, 2019 - journals.lww.com
Methods: U266 myeloma cells were cultured in 25 or 75 cm 2 flasks by using cell culture
medium mixtures obtained with the supplementation of 10 per cent foetal bovine serum and …