The rapid development of such research field as multi-omics and artificial intelligence (AI)
has made it possible to acquire and analyze the multi-dimensional big data of human …

Current treatment options for epilepsy are inadequate, as too many patients suffer from
uncontrolled seizures and from negative side effects of treatment. In addition to these clinical …

Sequencing-based studies have identified novel risk genes associated with severe
epilepsies and revealed an excess of rare deleterious variation in less-severe forms of …

Seizures are a disruption of normal brain activity present across a vast range of species and
conditions. We introduce an organizing principle that leads to the first objective Taxonomy of …

Objective Numerous studies have demonstrated increased load of de novo copy number
variants or single nucleotide variants in individuals with neurodevelopmental disorders …

Many encoded gene products responsible for neurodevelopmental disorders (NDs) like
autism spectrum disorders (ASD), schizophrenia (SCZ), intellectual disability (ID), and …

Epilepsy is a heterogeneous condition with disparate etiologies and phenotypic and
genotypic characteristics. Clinical and research aspects are accordingly varied, ranging from …

Infantile spasms (IS) and Lennox–Gastaut syndrome (LGS) are epileptic encephalopathies
characterized by early onset, intractable seizures, and poor developmental outcomes. De …

Abstract Background Neurodevelopmental disorders (NDDs) such as autism spectrum
disorder, intellectual disability, developmental disability, and epilepsy are characterized by …

ABSTRACT BACKGROUND No large-scale studies have specifically evaluated the
outcomes of infantile spasms (IS) of unknown cause, previously known as cryptogenic or …