Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …

Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …

Background Evidence from observational studies and clinical trials suggests that the gut
microbiota is associated with cancer. However, the causal association between gut …

This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …

Mendelian randomization (MR) is the use of genetic variants associated with an exposure to
estimate the causal effect of that exposure on an outcome. Mediation analysis is the method …

Stroke is the second leading cause of death with substantial unmet therapeutic needs. To
identify potential stroke therapeutic targets, we estimate the causal effects of 308 plasma …

Background Obesity is observationally associated with altered risk of many female
reproductive conditions. These include polycystic ovary syndrome (PCOS), abnormal uterine …

Multivariable Mendelian randomization (MVMR) is a form of instrumental variable analysis
which estimates the direct effect of multiple exposures on an outcome using genetic variants …

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides
thorough coverage of the methods and practical elements of Mendelian randomization …

Background: Observational studies suggested that residual risk of cardiovascular events
after LDL (low-density lipoprotein) cholesterol lowering may be linked to remnant cholesterol …