Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

The immune system enables organisms to combat infections and to eliminate endogenous
challenges. Immune responses can be evoked through diverse inducible pathways …

IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and
enhanced effector functions, including highly efficient pathogen neutralisation and …

More than 80 different adenovirus (AdV) types infect humans through the respiratory, ocular,
or gastrointestinal tracts. They cause acute clinical mani-festations or persist under humoral …

The consequences of human adenovirus (HAdV) infections are generally mild. However,
despite the perception that HAdVs are harmless, infections can cause severe disease in …

Complement C4, a key molecule in the complement system that is one of chief constituents
of innate immunity for immediate recognition and elimination of invading microbes, plays an …

Tripartite motif containing-21 (TRIM21) is a cytosolic ubiquitin ligase and antibody receptor
that provides a last line of defense against invading viruses. It does so by acting as a sensor …

Oncolytic virus therapy is a cancer treatment modality that has the potential to improve
outcomes for patients with currently incurable malignancies. Although intravascular delivery …

The expression of cytokines and chemokines in response to adenovirus infection is tightly
regulated by the innate immune system. Cytokine-mediated toxicity and cytokine storm are …

Antibody‐dependent complement activity is associated not only with autoimmune morbidity,
but also with antitumor efficacy. In infectious disease, both recombinant monoclonal …