Genetic and transcriptomic characteristics of RhlR-dependent quorum sensing in cystic fibrosis isolates of Pseudomonas aeruginosa

KL Asfahl, NE Smalley, AP Chang, AA Dandekar - Msystems, 2022 - Am Soc Microbiol
In people with the genetic disease cystic fibrosis (CF), bacterial infections involving the
opportunistic pathogen Pseudomonas aeruginosa are a significant cause of morbidity and …

Relationship of the transcription factor MexT to quorum sensing and virulence in Pseudomonas aeruginosa

M Kostylev, NE Smalley, MH Chao… - Journal of …, 2023 - Am Soc Microbiol
Quorum sensing (QS) regulates expression of many virulence genes in the opportunistic
human pathogen Pseudomonas aeruginosa. There are two acyl-homoserine lactone (AHL) …

The relationship between pqs gene expression and acylhomoserine lactone signaling in Pseudomonas aeruginosa

MP Soto-Aceves, NE Smalley, AL Schaefer… - Journal of …, 2024 - journals.asm.org
The opportunistic pathogen Pseudomonas aeruginosa has complex quorum sensing (QS)
circuitry, which involves two acylhomoserine lactone (AHL) systems, the LasI AHL synthase …

A balancing act: investigations on the impact of altered signal sensitivity in bacterial quorum sensing

SW Miranda, EP Greenberg - Journal of Bacteriology, 2023 - Am Soc Microbiol
Many bacterial species communicate and cooperate with kin using a form of cell-cell
signaling called quorum sensing. Sensitivity and selectivity are fundamental properties of …

Evolution of Quorum Sensing in Pseudomonas aeruginosa Can Occur via Loss of Function and Regulon Modulation

P Jayakumar, ART Figueiredo, R Kümmerli - Msystems, 2022 - Am Soc Microbiol
Pseudomonas aeruginosa populations evolving in cystic fibrosis lungs, animal hosts, natural
environments and in vitro undergo extensive genetic adaption and diversification. A …

Targeted deletion of Pf prophages from diverse Pseudomonas aeruginosa isolates has differential impacts on quorum sensing and virulence traits

AK Schmidt, CM Schwartzkopf, JD Pourtois… - Journal of …, 2024 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that commonly causes
medical hardware, wound, and respiratory infections. Temperate filamentous Pf phages that …

A Mesorhizobium japonicum quorum sensing circuit that involves three linked genes and an unusual acyl-homoserine lactone signal

Z Suo, DA Cummings Jr, AW Puri, AL Schaefer… - Mbio, 2023 - Am Soc Microbiol
Members of the genus Mesorhizobium, which are core components of the rhizosphere and
specific symbionts of legume plants, possess genes for acyl-homoserine lactone (AHL) …