VSMC s in resistance arteries and arterioles express a diverse array of KV channels with
members of the KV 1, KV 2 and KV 7 families being particularly important. Members of the …

Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …

Brain pericytes reside on the abluminal surface of capillaries, and their processes cover~
90% of the length of the capillary bed. These cells were first described almost 150 years ago …

Background Isovaleric acid (IVA) is a 5-carbon branched-chain fatty acid present in
fermented foods and produced in the colon by bacterial fermentation of leucine. We …

Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological
impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic …

Abstract Kv7. 1-Kv7. 5 (KCNQ1–5) K+ channels are voltage-gated K+ channels with major
roles in neurons, muscle cells and epithelia where they underlie physiologically important …

Objective—To establish the role of Kv7 channels in EPAC (exchange protein directly
activated by cAMP)-dependent relaxations of the rat vasculature and to investigate whether …

We identified six novel de novo human KCNQ5 variants in children with motor/language
delay, intellectual disability (ID), and/or epilepsy by whole exome sequencing. These …

Hypertension is a prevalent health problem inducing many organ damages. The
pathogenesis of hypertension involves a complex integration of different organ systems …

Numerous mediators and drugs regulate blood flow or arterial pressure by acting on
vascular tone, involving cyclic nucleotide intracellular pathways. These signals lead to …