Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as
disease-causing agents since they are misfolded proteins. Prion diseases are called" …

Abstract 26S proteasome is an intracellular; ATP dependent enzymatic complex degrades
ubiquitin-tagged proteins and maintains cellular homeostasis. The orderly degraded …

The interactions involving the side chains of weakly polar aromatic amino acid residues, eg,
Phenylalanine (Phe), Tyrosine (Tyr) and Tryptophan (Trp) generally reside at the interior of …

PrP has two regions: unstructured region PrP (1–120) and structured region PrP (119–231).
In the structured region, there are many segments which have the property of amyloid fibril …

Cβ-Cα (θ2) bonds. A large body of crystallographic evidence has been presented, which
suggests that in the case of Gpn θ1, and θ2, are largely restricted to gauche conformations …

Synthetic approaches to construction of designed proteins have primarily relied on the
known secondary structure-forming propensities of amino acids, gleaned from analysis of …

While, intramolecular hydrogen bonds have attracted the greatest attention in studies of
peptide conformations, the recognition that several other weakly polar interactions may be …

Over the last 20 years, a large body of work in the literature has focused on the folded
structures formed by peptide sequences containing backbone homologated residues …