The increasing prevalence of diabetes and its complications, such as cardiovascular and
kidney disease, remains a huge burden globally. Identification of biomarkers for the …

Aims/hypothesis The aim of this study was to use Mendelian randomisation (MR) to identify
the causal risk factors for type 2 diabetes. Methods We first conducted a review of meta …

Prospective observational studies support the use of long-chain omega-3 polyunsaturated
fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; …

Colonocyte metabolism shapes the microbiome. Metabolites are the main mediators of
information exchange between intestine and microbial communities. Arachidonic acid (AA) …

Aims Observational studies show inconsistent associations of red meat consumption with
cardiovascular disease (CVD) and diabetes. Moreover, red meat consumption varies by sex …

Passive permeability is a key property in drug disposition and delivery. It is critical for
gastrointestinal absorption, brain penetration, renal reabsorption, defining clearance …

Diabetes and its complications cause a heavy disease burden globally. Identifying
exposures, risk factors and molecular processes causally associated with the development …

Genetic studies have identified≥ 240 loci associated with the risk of type 2 diabetes (T2D),
yet most of these loci lie in non-coding regions, masking the underlying molecular …

Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

Polyunsaturated fatty acids (PUFAs) are long chain fatty acids that are characterized by the
presence of more than one double bond. These include fatty acids such as ꞷ-3-α-linolenic …