Eukaryotic cell surfaces are decorated with a complex array of glycoconjugates that are
usually capped with sialic acids, a large family of over 50 structurally distinct nine-carbon …

Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with
negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived …

N‐Acetylglucosamine‐6‐phosphate deacetylase (NagA) and glucosamine‐6‐phosphate
deaminase (NagB) are branch point enzymes that direct amino sugars into different …

In environments where glucose is limited, some pathogenic bacteria metabolize host-
derived sialic acid as a nutrient source. N-Acetylmannosamine kinase (NanK) is the second …

There are five known general catalytic mechanisms used by enzymes to catalyze
carbohydrate epimerization. The amino sugar epimerase N-acetylmannosamine-6 …

Abstract N‐acetylglucosamine 6‐phosphate deacetylase (NagA) catalyzes the conversion of
N‐acetylglucosamine‐6‐phosphate to glucosamine‐6‐phosphate in amino sugar …

Sialic acids are nine-carbon sugars that are found abundantly on the cell surfaces of
mammals as glycoprotein or glycolipid complexes. Several Gram-negative and Gram …

Sialic acids are nine-carbon sugars that are found abundantly on the cell surfaces of
mammals as glycoprotein or glycolipid complexes. Several Gram-negative and Gram …

The principal aim of this thesis is to build an understanding of how amino sugars are
metabolised in a clinically relevant strain of Staphylococcus aureus. Amino sugars, such as …