Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

X Zhao, J Liu, J Fan, H Chao, X Peng - Chemical Society Reviews, 2021 - pubs.rsc.org
Photodynamic therapy (PDT), a therapeutic mode involving light triggering, has been
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …

Mito‐bomb: targeting mitochondria for cancer therapy

X Guo, N Yang, W Ji, H Zhang, X Dong… - Advanced …, 2021 - Wiley Online Library
Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …

Copper-induced tumor cell death mechanisms and antitumor theragnostic applications of copper complexes

Y Jiang, Z Huo, X Qi, T Zuo, Z Wu - Nanomedicine, 2022 - Taylor & Francis
Recent studies found that unbalanced copper homeostasis affect tumor growth, causing
irreversible damage. Copper can induce multiple forms of cell death, including apoptosis …

Transition metal complexes as photosensitisers in one-and two-photon photodynamic therapy

LK McKenzie, HE Bryant, JA Weinstein - Coordination Chemistry Reviews, 2019 - Elsevier
Photodynamic therapy (PDT) exploits light-activated compounds for therapeutic use. It relies
on a photosensitiser (PS) that is inactive in the absence of light. When irradiated, the PS …

Highly Efficient Far‐Red/NIR‐Absorbing Neutral Ir (III) Complex Micelles for Potent Photodynamic/Photothermal Therapy

B Liu, J Jiao, W Xu, M Zhang, P Cui, Z Guo… - Advanced …, 2021 - Wiley Online Library
A critical issue in photodynamic therapy (PDT) is inadequate reactive oxygen species (ROS)
generation in tumors, causing inevitable survival of tumor cells that usually results in tumor …

Cyclometalated iridium (III) luminescent complexes in therapy and phototherapy

A Zamora, G Vigueras, V Rodríguez… - Coordination Chemistry …, 2018 - Elsevier
Octahedral Ir (III) complexes bearing cyclometalated ligands exhibit a great stability in
biological media and are excellent therapeutical and phototherapeutical candidates for …

Molecular photosensitisers for two-photon photodynamic therapy

F Bolze, S Jenni, A Sour, V Heitz - Chemical Communications, 2017 - pubs.rsc.org
Two-photon excitation has attracted the attention of biologists, especially after the
development of two-photon excited microscopy in the nineties. Since then, new applications …

Single-cell chemistry of photoactivatable platinum anticancer complexes

EM Bolitho, C Sanchez-Cano, H Shi… - Journal of the …, 2021 - ACS Publications
The Pt (IV) prodrug trans, trans, trans-[Pt (pyridine) 2 (N3) 2 (OH) 2](Pt1) and its coumarin
derivative trans, trans, trans-[Pt (pyridine) 2 (N3) 2 (OH)(coumarin-3-carboxylate)](Pt2) are …

Cyclometalated iridium (III) complexes for life science

C Caporale, M Massi - Coordination Chemistry Reviews, 2018 - Elsevier
Photoluminescent cyclometalated iridium (III) complexes are now a well established class of
organometallic compounds with advantageous potential applications in biology and life …