A plea for personalization of the hemodynamic management of septic shock

D De Backer, M Cecconi, MS Chew, L Hajjar, X Monnet… - Critical care, 2022 - Springer
Although guidelines provide excellent expert guidance for managing patients with septic
shock, they leave room for personalization according to patients' condition. Hemodynamic …

Regulation of blood flow and volume exchange across the microcirculation

M Jacob, D Chappell, BF Becker - Critical care, 2016 - Springer
Oxygen delivery to cells is the basic prerequisite of life. Within the human body, an
ingenious oxygen delivery system, comprising steps of convection and diffusion from the …

Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy

A Perner, AC Gordon, D De Backer, G Dimopoulos… - Intensive care …, 2016 - Springer
Sepsis is a major growing global burden and a major challenge to intensive care clinicians,
researchers, guideline committee members and policy makers, because of its high and …

Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock?

GA Ospina-Tascon, M Umaña, WF Bermúdez… - Intensive care …, 2016 - Springer
Purpose Septic shock has been associated with microvascular alterations and these in turn
with the development of organ dysfunction. Despite advances in video microscopic …

[HTML][HTML] Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock

J Mallat, M Lemyze, L Tronchon, B Vallet… - World journal of critical …, 2016 - ncbi.nlm.nih.gov
The mixed venous-to-arterial carbon dioxide (CO 2) tension difference [P (va) CO 2] is the
difference between carbon dioxide tension (PCO 2) in mixed venous blood (sampled from a …

Pathophysiology and clinical implications of the veno-arterial PCO2 gap

Z Ltaief, AG Schneider, L Liaudet - Critical Care, 2021 - Springer
This article is one of ten reviews selected from the Annual Update in Intensive Care and
Emergency Medicine 2021. Other selected articles can be found online at https://www …

Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O2 content difference ratio as markers of resuscitation in patients with septic shock

GA Ospina-Tascón, M Umaña, W Bermúdez… - Intensive care …, 2015 - Springer
Purpose To evaluate the prognostic value of the Cv-aCO 2/Da-vO 2 ratio combined with
lactate levels during the early phases of resuscitation in septic shock. Methods Prospective …

Central venous-to-arterial carbon dioxide difference combined with arterial-to-venous oxygen content difference is associated with lactate evolution in the …

J Mesquida, P Saludes, G Gruartmoner, C Espinal… - Critical care, 2015 - Springer
Introduction Since normal or high central venous oxygen saturation (ScvO 2) values cannot
discriminate if tissue perfusion is adequate, integrating other markers of tissue hypoxia, such …

Perfusion indices revisited

A Hasanin, A Mukhtar, H Nassar - Journal of intensive care, 2017 - Springer
Monitoring of tissue perfusion is an essential step in the management of acute circulatory
failure. The presence of cellular dysfunction has been a basic component of shock definition …

[HTML][HTML] How can CO2-derived indices guide resuscitation in critically ill patients?

F Gavelli, JL Teboul, X Monnet - Journal of thoracic disease, 2019 - ncbi.nlm.nih.gov
Assessing the adequacy of oxygen delivery with oxygen requirements is one of the key-goal
of haemodynamic resuscitation. Clinical examination, lactate and central or mixed venous …