Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …

Wnt signaling is an evolutionary cell‐to‐cell coordination mechanism and it is highly critical
for a variety of physiological processes of an organism's body, including stem cell …

The recent advances in in vitro 3D culture technologies, such as organoids, have opened
new avenues for the development of novel, more physiological human cancer models. Such …

The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication
system that is important for stem cell renewal, cell proliferation and cell differentiation both …

The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

Long non-coding RNAs (lncRNAs) are involved in the pathology of various tumors, including
colorectal cancer (CRC). The crosstalk between carcinoma-associated fibroblasts (CAFs) …

Adult stem cell-derived organoids are three-dimensional epithelial structures that
recapitulate fundamental aspects of their organ of origin. We describe conditions for the long …

Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte
proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem …