Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Developing PROTACs to redirect the ubiquitination activity of E3 ligases and potently
degrade a target protein within cells can be a lengthy and unpredictable process, and it …

Epigenetic and genetic alterations have long been thought of as two separate mechanisms
participating in carcinogenesis. A recent outcome of whole exome sequencing of thousands …

SWI/SNF chromatin remodelling complexes use the energy of ATP hydrolysis to remodel
nucleosomes and to modulate transcription. Growing evidence indicates that these …

Cancer is a disease associated with genomic instability that often results from oncogene
activation. This in turn leads to hyperproliferation and replication stress. However, the …

Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …

Systematic identification of noncoding regulatory elements has, to date, mainly relied on
large-scale reporter assays that do not reproduce endogenous conditions. We present two …

Binding within or nearby target genes involved in cell proliferation and survival enables the
p53 tumor suppressor gene to regulate their transcription and cell-cycle progression. Using …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …