In response to osmotic dehydration cells sense, signal, alter gene expression, and
metabolically counterbalance osmotic differences. The main compatible solute/osmolyte that …

The cellular ability to react to environmental fluctuations depends on signaling networks that
are controlled by the dynamic activities of kinases and phosphatases. Here, to gain insight …

To cope with sudden changes in the external environment, the budding yeast
Saccharomyces cerevisiae orchestrates a multifaceted response that spans many levels of …

Although ribosome assembly is quality controlled to maintain protein homeostasis, different
ribosome populations have been described. How these form, especially under stress …

Protein Kinase A (PKA) is an essential kinase that is conserved across eukaryotes and plays
fundamental roles in a wide range of organismal processes, including growth control …

Post-translational modifications of proteins play an important role in the regulation of cellular
processes. The mass spectrometry analysis of proteome modifications offers huge potential …

Microbes can be metabolically engineered to produce biofuels and biochemicals, but
rerouting metabolic flux toward products is a major hurdle without a systems-level …

We present a method for automatically discovering signaling pathways from time-resolved
phosphoproteomic data. The Temporal Pathway Synthesizer (TPS) algorithm uses …

Hypoxia has profound and diverse effects on aerobic organisms, disrupting oxidative
phosphorylation and activating several protective pathways. Predictions have been made …

Appressoria are important mediators of plant–microbe interactions. In the devastating rice
blast pathogen Magnaporthe oryzae, appressorial morphogenesis from germ tube tips …