Role of mitochondrial stress protein HSP60 in diabetes‐induced neuroinflammation

DSNK Liyanagamage… - Mediators of inflammation, 2020 - Wiley Online Library
Diabetes mellitus is the most common metabolic disorder characterized by hyperglycemia
and associated malfunctions of the metabolism of carbohydrates, proteins, and lipids. There …

High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes

H Rizwan, S Pal, S Sabnam, A Pal - Life sciences, 2020 - Elsevier
Mitochondria are fascinating structures of the cellular compartments that generate energy to
run the cells. However, inherent disorders of mitochondria due to diabetes can cause major …

Heat shock proteins with an emphasis on HSP 60

JA Malik, R Lone - Molecular Biology Reports, 2021 - Springer
Heat shock phenomenon is a process by which cells express a set of proteins called heat
shock proteins (HSPs) against heat stress. HSPs include several families depending upon …

[HTML][HTML] The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome

S Reeg, T Jung, JP Castro, KJA Davies… - Free Radical Biology …, 2016 - Elsevier
One hallmark of aging is the accumulation of protein aggregates, promoted by the unfolding
of oxidized proteins. Unraveling the mechanism by which oxidized proteins are degraded …

[HTML][HTML] Molybdenum and cadmium co-induce hypothalamus toxicity in ducks via disturbing Nrf2-mediated defense response and triggering mitophagy

T Cui, W Jiang, F Yang, J Luo, R Hu, H Cao… - Ecotoxicology and …, 2021 - Elsevier
Growing evidences reveal that Nrf2-mediated antioxidant defense response and mitophagy
are involved in the toxic mechanism of heavy metals, but the effects of molybdenum (Mo) …

Involvement of the heat shock response (HSR) regulatory pathway in cadmium-elicited cerebral damage

M Talukder, SS Bi, MW Lv, J Ge, C Zhang… - … Science and Pollution …, 2023 - Springer
The heat shock response (HSR) is a cellular protective mechanism that is characterized by
the induction of heat shock transcription factors (HSFs) and heat shock proteins (HSPs) in …

Nutrient-induced inflammation in polycystic ovary syndrome: role in the development of metabolic aberration and ovarian dysfunction

F González - Seminars in reproductive medicine, 2015 - thieme-connect.com
A pathophysiology paradigm shift has emerged with the discovery that polycystic ovary
syndrome (PCOS) is a proinflammatory state. Despite the dogma that the compensatory …

The role of heat shock proteins in oxidative stress damage induced by Se deficiency in chicken livers

CP Liu, J Fu, FP Xu, XS Wang, S Li - Biometals, 2015 - Springer
Selenium (Se) is an essential dietary trace element, which acts as an antioxidant. Heat
shock proteins (HSPs) are a family of intracellular proteins whose synthesis is greatly …

New insights into the role and therapeutic potential of HSP70 in diabetes

AA de Oliveira, VO Mendoza, S Rastogi… - Pharmacological …, 2022 - Elsevier
Emerging evidence indicates that HSP70 represents a key mechanism in the
pathophysiology of β-cell dysfunction, insulin resistance, and various diabetic complications …

[HTML][HTML] 17β-estradiol on the expression of G-protein coupled estrogen receptor (GPER/GPR30) mitophagy, and the PI3K/Akt signaling pathway in ATDC5 …

D Fan, X Yang, Y Li, L Guo - Medical science monitor: international …, 2018 - ncbi.nlm.nih.gov
Background Osteoarthritis is a progressive inflammatory joint disease resulting in damage to
articular cartilage. G-protein coupled estrogen receptor (GPER/GPR30) activates cell …