Glutamine reliance in cell metabolism

HC Yoo, YC Yu, Y Sung, JM Han - Experimental & molecular medicine, 2020 - nature.com
As knowledge of cell metabolism has advanced, glutamine has been considered an
important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study …

Molecular mechanisms of ferroptosis and its role in cancer therapy

T Xu, W Ding, X Ji, X Ao, Y Liu, W Yu… - Journal of cellular and …, 2019 - Wiley Online Library
Ferroptosis is a newly defined programmed cell death process with the hallmark of the
accumulation of iron‐dependent lipid peroxides. The term was first coined in 2012 by the …

Cancer-associated adipocytes: key players in breast cancer progression

Q Wu, B Li, Z Li, J Li, S Sun, S Sun - Journal of hematology & oncology, 2019 - Springer
Adipocytes are one of the primary stromal cells in many tissues, and they are considered to
play an active role in the tumor microenvironment. Cancer-associated adipocytes (CAAs) …

[HTML][HTML] Autophagy in health and disease: A comprehensive review

S Saha, DP Panigrahi, S Patil, SK Bhutia - Biomedicine & pharmacotherapy, 2018 - Elsevier
Autophagy, a conserved catabolic process, plays an immensely significant role in a variety
of diseases. However, whether it imparts a protective function in diseases remains …

Phosphorylation of PDHA by AMPK drives TCA cycle to promote cancer metastasis

Z Cai, CF Li, F Han, C Liu, A Zhang, CC Hsu, D Peng… - Molecular cell, 2020 - cell.com
Cancer metastasis accounts for the major cause of cancer-related deaths. How
disseminated cancer cells cope with hostile microenvironments in secondary site for full …

Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

H Rundqvist, P Veliça, L Barbieri, PA Gameiro… - Elife, 2020 - elifesciences.org
Exercise has a wide range of systemic effects. In animal models, repeated exertion reduces
malignant tumor progression, and clinically, exercise can improve outcome for cancer …

IL‐1β‐induced elevation of solute carrier family 7 member 11 promotes hepatocellular carcinoma metastasis through up‐regulating programmed death ligand 1 and …

Q He, M Liu, W Huang, X Chen, B Zhang, T Zhang… - …, 2021 - Wiley Online Library
Background and Aims Because of a paucity of effective treatment options, metastasis is still
a major cause for HCC‐associated mortality. The molecular mechanism of inflammation …

The interplay of reactive oxygen species, hypoxia, inflammation, and sirtuins in cancer initiation and progression

M Tafani, L Sansone, F Limana… - Oxidative medicine …, 2016 - Wiley Online Library
The presence of ROS is a constant feature in living cells metabolizing O2. ROS
concentration and compartmentation determine their physiological or pathological effects …

mTORC1 as a regulator of mitochondrial functions and a therapeutic target in cancer

KG de la Cruz López, ME Toledo Guzmán… - Frontiers in …, 2019 - frontiersin.org
Continuous proliferation of tumor cells requires constant adaptations of energy metabolism
to rapidly fuel cell growth and division. This energetic adaptation often comprises …

S‐adenosylmethionine: a metabolite critical to the regulation of autophagy

Y Ouyang, Q Wu, J Li, S Sun, S Sun - Cell proliferation, 2020 - Wiley Online Library
Autophagy is a mechanism that enables cells to maintain cellular homeostasis by removing
damaged materials and mobilizing energy reserves in conditions of starvation. Although …