Asymmetric organocatalysis: an enabling technology for medicinal chemistry

B Han, XH He, YQ Liu, G He, C Peng… - Chemical Society Reviews, 2021 - pubs.rsc.org
The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

Bifunctional amine‐squaramides: powerful hydrogen‐bonding organocatalysts for asymmetric domino/cascade reactions

P Chauhan, S Mahajan, U Kaya… - … Synthesis & Catalysis, 2015 - Wiley Online Library
Organocatalytic domino/cascade reactions provide a convenient method for the construction
of complex molecular structures bearing multiple stereocenters in a highly stereoselective …

Squaramide‐catalyzed asymmetric reactions

BL Zhao, JH Li, DM Du - The Chemical Record, 2017 - Wiley Online Library
Bifunctional squaramides have emerged as powerful hydrogen‐bonding catalysts for
promoting a wide array of useful asymmetric reactions, which provides convenient methods …

Enantioselective Synthesis of AG‐041R by using N‐Heteroarenesulfonyl Cinchona Alkaloid Amides as Organocatalysts

N Hara, S Nakamura, M Sano, R Tamura… - … A European Journal, 2012 - Wiley Online Library
The organocatalytic enantioselective decarboxylative addition of malonic acid half thioesters
to ketimines derived from isatins by using N‐heteroarenesulfonyl cinchona alkaloid amides …

Stereoselective reactions of nitro compounds in the synthesis of natural compound analogs and active pharmaceutical ingredients

AY Sukhorukov, AA Sukhanova, SG Zlotin - Tetrahedron, 2016 - Elsevier
Nitroalkanes and nitroalkenes have been always considered as convenient and readily
available intermediates in organic synthesis, including total synthesis of natural products. 1 …

Catalytic enantioselective decarboxylative reactions using organocatalysts

S Nakamura - Organic & Biomolecular Chemistry, 2014 - pubs.rsc.org
Catalytic decarboxylative reactions are attractive as biomimetic reactions and
environmentally friendly reaction processes. In this review, the origin and recent …

Membrane-grafted asymmetric organocatalyst for an integrated synthesis–separation platform

C Didaskalou, J Kupai, L Cseri, J Barabas, E Vass… - ACS …, 2018 - ACS Publications
In this work we introduce a sustainable membrane-based synthesis–separation platform for
enantioselective organocatalysis. An azido derivatized cinchona-squaramide bifunctional …

Recent advances in catalytic asymmetric decarboxylative addition reactions

ZL Wang - Advanced Synthesis & Catalysis, 2013 - Wiley Online Library
This review examines recent advances in asymmetric catalytic decarboxylative addition
reactions which have become a powerful method to form C C and C X bond using …

Unprecedented hydrophobic amplification in noncovalent organocatalysis “on water”: hydrophobic chiral squaramide catalyzed Michael addition of malonates to …

HY Bae, CE Song - ACS Catalysis, 2015 - ACS Publications
In this study, water was demonstrated to be an exceptionally efficient reaction medium for
the noncovalent, hydrogen-bonding-promoted enantioselective Michael addition of …

Hydrogen-bond-mediated cascade reaction involving chalcones: Facile synthesis of enantioenriched trisubstituted tetrahydrothiophenes

JB Ling, Y Su, HL Zhu, GY Wang, PF Xu - Organic letters, 2012 - ACS Publications
A bifunctional squaramide catalyzed sulfa-Michael/aldol cascade reaction between 1, 4-
dithiane-2, 5-diol and chalcones with a low catalyst loading has been developed …