Interaction between transmembrane helices often determines biological activity of
membrane proteins. Bitopic proteins, a broad subclass of membrane proteins, form dimers …

The plasma membrane is a complex system, consisting of two layers of lipids and proteins
compartmentalized into small structures called nanodomains. Despite the asymmetric …

Proton translocation through lipid membranes is a fundamental process in the field of
biology. Several theoretical models have been developed and presented over the years to …

For macromolecular structures determined by cryogenic electron microscopy, no technique
currently exists for mapping elements to defined locations, leading to errors in the …

We measured the effect of intrinsic lipid curvature, J 0, on structural properties of asymmetric
vesicles made of palmitoyl-oleoyl-phosphatidylethanolamine (POPE; J 0< 0) and palmitoyl …

The lateral mobility of proteins within cell membranes is usually thought to be dependent on
their size and modulated by local heterogeneities of the membrane. Experiments using …

The human epidermal growth factor receptor (EGFR) of HER/ErbB receptor tyrosine kinase
family mediates a broad spectrum of cellular responses transducing biochemical signals via …

When micron-scale compositional heterogeneity develops in membranes, the distribution of
lipids on one face of the membrane strongly affects the distribution on the other. Specifically …

The mechanism responsible for domain registration in two membrane leaflets has thus far
remained enigmatic. Using continuum elasticity theory, we show that minimum line tension …

Liquid-ordered lipid domains represent a lateral inhomogeneity in cellular membranes.
These domains have elastic and physicochemical properties different from those of the …