The glutathione S-transferases (GST) are a supergene family of dimeric, enzymes that
catalyse the conjugation of glutathione (GSH) to a variety of electrophiles including arene …

Despite overwhelming evidence of tobacco's harmful effects and pressure from anti-smoking
advocates, current surveys show that about one-quarter of all adults in the United States are …

An essential resource for all scientists researching cellular responses to DNA damage.•
Introduces important new material reflective of the major changes and developments that …

Abstract Using the International Project on Genetic Susceptibility to Environmental
Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) …

The association between glutathione S-transferase (GST) activity as measured by 1-chloro-
2, 4-dinitrobenzene (CDNB) conjugation and genotype at exon 5 and exon 6 of the human …

Cytogenetic biomarkers have long been applied in surveillance of human genotoxic
exposure and early effects of genotoxic carcinogens. Due to their wide use, it has been …

Prostatic hyperplasia (PH) is a common urologic disease that affects mostly elderly men. PH
can be classified as benign prostatic hyperplasia (BPH), or prostate cancer (PCa) based on …

Importance of the field: The Glutathione S-transferases (GSTs) have advanced beyond the
classic view of their role in metabolism and are encouraging scientists to assess new …

Two population-based, case-control studies have documented reduced risk of prostate
cancer in men who consume cruciferous vegetables. Cruciferae contain high levels of the …

The activity of chemical carcinogens is a complex balance between metabolic activation by
cytochrome P450 monooxygenases and detoxification by enzymes such as glutathione S …