Identifying the interactions established by a protein of interest can be a critical step in
understanding its function. This is especially true when an unknown protein of interest is …

Tag-assisted protein purification is a method of choice for both academic researches and
large-scale industrial demands. Application of the purification tags in the protein production …

INTRODUCTION Mutations in two genes, PKD1 and PKD2, are responsible for about 85 and
10% of all cases of autosomal dominant polycystic kidney disease (ADPKD), one of the most …

Although transcriptional regulation of stem cell pluripotency and differentiation has been
extensively studied, only a small number of studies have addressed the roles for …

The purification of recombinant proteins by affinity chromatography is one of the most
efficient strategies due to the high recovery yields and purity achieved. However, this is …

Sensitization of the capsaicin receptor TRPV1 is central to the initiation of pathological forms
of pain, and multiple signaling cascades are known to enhance TRPV1 activity under …

Virtually all recombinant proteins are now prepared using fusion domains also known as
“tags”. The use of tags helps to solve some serious problems: to simplify procedures of …

Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and
sporadic Parkinson's disease (PD). LRRK2 is a complex protein that consists of multiple …

Mutations in leucine-rich repeat kinase 2 (LRRK2) that increase its kinase activity associate
with familial forms of Parkinson disease (PD). As phosphorylation determines the functional …

Proteins play a fundamental role in establishing the diversity of cellular processes in health
or disease systems. This diversity is accomplished by a vast array of protein functions. In …