Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Signal transducer and activator of transcription (STAT) 3 is one of the most complex
regulators of transcription. Constitutive activation of STAT3 has been reported in many types …

Abstract Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor
with many important functions in the biology of normal and transformed cells. Its regulation is …

Cytokines are pleotrophic proteins that coordinate the host response to infection as well as
mediate normal, ongoing signaling between cells of nonimmune tissues, including the …

Autism spectrum disorders (ASD) are neurodevelopmental diseases that affect an alarming
number of individuals. The etiological basis of ASD is unclear, and evidence suggests it …

Signal transducer and activator of transcription 3 (STAT3) regulates diverse cellular
processes, including cell growth, differentiation, and apoptosis, and is frequently activated …

The Notch pathway is prominent among those known to regulate neural development in
vertebrates. Notch receptor activation can inhibit neurogenesis, maintain neural progenitor …

Glioblastoma multiforme (GBM) is the most malignant and aggressive type of brain tumor
with an average life expectancy of less than 15 months. This is mostly due to the highly …

The temporally and spatially restricted nature of the differentiation capacity of cells in the
neural lineage has been studied extensively in recent years. Epigenetic control of …

During mammalian development, neuroepithelial cells function as mitotic progenitors, which
self-renew and generate neurons. Although spindle orientation is important for such …