Lessons learned from clinical trials using antimicrobial peptides (AMPs)

GS Dijksteel, MMW Ulrich, E Middelkoop… - Frontiers in …, 2021 - frontiersin.org
Antimicrobial peptides (AMPs) or host defense peptides protect the host against various
pathogens such as yeast, fungi, viruses and bacteria. AMPs also display immunomodulatory …

Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability

Z Lai, X Yuan, H Chen, Y Zhu, N Dong, A Shan - Biotechnology Advances, 2022 - Elsevier
Due to the alarming developing rate of multidrug-resistant bacterial pathogens, the
development and modification of antimicrobial peptides (AMPs) are unprecedentedly active …

Topical antimicrobial peptide formulations for wound healing: Current developments and future prospects

RK Thapa, DB Diep, HH Tønnesen - Acta biomaterialia, 2020 - Elsevier
Antimicrobial peptides (AMPs) are the natural antibiotics recognized for their potent
antibacterial and wound healing properties. Bare AMPs have limited activity following topical …

Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

Y Jiang, Y Chen, Z Song, Z Tan, J Cheng - Advanced Drug Delivery …, 2021 - Elsevier
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …

Antimicrobial peptides and their therapeutic potential for bacterial skin infections and wounds

A Pfalzgraff, K Brandenburg, G Weindl - Frontiers in pharmacology, 2018 - frontiersin.org
Alarming data about increasing resistance to conventional antibiotics are reported, while at
the same time the development of new antibiotics is stagnating. Skin and soft tissue …

D- and Unnatural Amino Acid Substituted Antimicrobial Peptides With Improved Proteolytic Resistance and Their Proteolytic Degradation Characteristics

J Lu, H Xu, J Xia, J Ma, J Xu, Y Li, J Feng - Frontiers in microbiology, 2020 - frontiersin.org
The transition of antimicrobial peptides (AMPs) from the laboratory to market has been
severely hindered by their instability toward proteases in biological systems. In the present …

Strategies for antimicrobial peptide coatings on medical devices: A review and regulatory science perspective

M Kazemzadeh-Narbat, H Cheng… - Critical reviews in …, 2021 - Taylor & Francis
Indwelling and implanted medical devices are subject to contamination by microbial
pathogens during surgery, insertion or injection, and ongoing use, often resulting in severe …

Antimicrobial peptides: key components of the innate immune system

M Pasupuleti, A Schmidtchen… - Critical reviews in …, 2012 - Taylor & Francis
Life-threatening infectious diseases are on their way to cause a worldwide crisis, as treating
them effectively is becoming increasingly difficult due to the emergence of antibiotic resistant …

Strategic approaches to optimizing peptide ADME properties

L Di - The AAPS journal, 2015 - Springer
Abstract Development of peptide drugs is challenging but also quite rewarding. Five
blockbuster peptide drugs are currently on the market, and six new peptides received first …

Delivery systems for antimicrobial peptides

R Nordström, M Malmsten - Advances in colloid and interface science, 2017 - Elsevier
Due to rapidly increasing resistance development against conventional antibiotics, finding
novel approaches for the treatment of infections has emerged as a key health issue …