Natural and traditional medicines, being a great source of drugs and drug leads, have
regained wide interests due to the limited success of high-throughput screening of …

The completion of the human genome sequencing project has provided a wealth of new
information regarding the genomic blueprint of the cell. Although, to date, there are roughly …

Assessment of protein dynamics in living cells is crucial for understanding their biological
properties and functions. The SNAP‐tag, a self labeling suicide enzyme, presents a tool with …

The hepatitis C virus (HCV) induces alterations of host cells to facilitate its life cycle. Fatty
acid synthase (FASN) is a multidomain enzyme that plays a key role in the biosynthesis of …

As many small bioactive molecules fulfill their functions through interacting with protein
targets, the identification of such targets is crucial in understanding their mechanisms of …

Protein functions are tightly regulated by their subcellular localization in live cells, and
quantitative evaluation of dynamically altered proteomes in each organelle should provide …

Tetrahydrolipstatin (THL) is bactericidal but its precise target spectrum is poorly
characterized. Here, we used a THL analog and activity-based protein profiling to identify …

Luminogens with aggregation‐induced emission feature (AIEgens) are highly demanded
because of its excellent performance in fluorescent bioprobes. In this work, three AIEgens …

The conjugation of proteins with synthetic molecules can be conducted in many different
ways. In this Perspective, we focus on tag-based techniques and specifically on the SNAP …

Activity-based protein profiling (ABPP) has become a powerful chemical proteomic
technology allowing the dissection of complex ligand–protein interactions in their native …