AKT kinase pathway: a leading target in cancer research

A Kumar, V Rajendran… - The Scientific World …, 2013 - Wiley Online Library
AKT1, a serine/threonine‐protein kinase also known as AKT kinase, is involved in the
regulation of various signalling downstream pathways including metabolism, cell …

Ubiquitin-mediated degradation of aurora kinases

C Lindon, R Grant, M Min - Frontiers in Oncology, 2016 - frontiersin.org
The Aurora kinases are essential regulators of mitosis in eukaryotes. In somatic cell
divisions of higher eukaryotes, the paralogs Aurora kinase A (AurA) and Aurora kinase B …

Use of long term molecular dynamics simulation in predicting cancer associated SNPs

A Kumar, R Purohit - PLoS computational biology, 2014 - journals.plos.org
Computational prediction of cancer associated SNPs from the large pool of SNP dataset is
now being used as a tool for detecting the probable oncogenes, which are further examined …

Evidence of colorectal cancer-associated mutation in MCAK: a computational report

A Kumar, V Rajendran, R Sethumadhavan… - Cell Biochemistry and …, 2013 - Springer
Computational prediction of disease-associated non-synonymous polymorphism (nsSNP)
has provided a significant platform to filter out the pathological mutations from large pool of …

2D-QSAR, molecular docking and MD simulation based virtual screening of the herbal molecules against Alzheimer's disorder: an approach to predict CNS activity

A Thakur, B Sharma, A Parashar… - Journal of …, 2024 - Taylor & Francis
Acetylcholinesterase (AChE) is one of the key enzyme targets that have been used clinically
for the management of Alzheimer's Disorder (AD). Numerous reports in the literature predict …

Cancer associated E17K mutation causes rapid conformational drift in AKT1 pleckstrin homology (PH) domain

A Kumar, R Purohit - PLoS One, 2013 - journals.plos.org
Background AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is one of the
most frequently activated proliferated and survival pathway of cancer. Recently it has been …

Bioinformatics analysis of markers based on m6A related to prognosis combined with immune invasion of renal clear cell carcinoma

L Liu, M Zhuang, X Tu, C Li, H Liu… - Cell Biology …, 2023 - Wiley Online Library
The incidence rate of renal cell carcinoma (RCC) is about 3% of all adult cancers. Of these,
the Kidney clear cell renal cell carcinoma (KIRC) is the most common type, accounting for …

Gain of native conformation of Aurora A S155R mutant by small molecules

G Tanwar, R Purohit - Journal of cellular biochemistry, 2019 - Wiley Online Library
Aurora A is a mitotic serine/threonine kinase protein that is a proposed target of the first‐line
anticancer drug design. It has been found to be overexpressed in many human cancer cells …

Computational SNP analysis: current approaches and future prospects

A Kumar, V Rajendran, R Sethumadhavan… - Cell Biochemistry and …, 2014 - Springer
The computational approaches in determining disease-associated Non-synonymous single
nucleotide polymorphisms (nsSNPs) have evolved very rapidly. Large number of deleterious …

Computational Analysis of Gly482Ser Single‐Nucleotide Polymorphism in PPARGC1A Gene Associated with CAD, NAFLD, T2DM, Obesity, Hypertension, and …

S Taghvaei, L Saremi, S Babaniamansour - PPAR research, 2021 - Wiley Online Library
Peroxisome proliferator‐activated receptor‐gamma coactivator 1‐alpha (PPARGC1A)
regulates the expression of energy metabolism's genes and mitochondrial biogenesis. The …