PET imaging of neuroinflammation in neurological disorders
A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …
characterise the inflammatory processes underlying various diseases and to inform the …
Non-invasive kinetic modelling approaches for quantitative analysis of brain PET studies
CWJ Van Der Weijden, P Mossel, AL Bartels… - European Journal of …, 2023 - Springer
Pharmacokinetic modelling with arterial sampling is the gold standard for analysing dynamic
PET data of the brain. However, the invasive character of arterial sampling prevents its …
PET data of the brain. However, the invasive character of arterial sampling prevents its …
Kinetic modeling and parameter estimation of TSPO PET imaging in the human brain
C Wimberley, S Lavisse, A Hillmer, R Hinz… - European journal of …, 2021 - Springer
Abstract Purpose Translocator protein 18-kDa (TSPO) imaging with positron emission
tomography (PET) is widely used in research studies of brain diseases that have a neuro …
tomography (PET) is widely used in research studies of brain diseases that have a neuro …
Have (R)-[11C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies
Purpose The prototypical TSPO radiotracer (R)-[11C] PK11195 has been used in humans
for more than thirty years to visualize neuroinflammation in several pathologies. Alternative …
for more than thirty years to visualize neuroinflammation in several pathologies. Alternative …
[18F]-DPA-714 PET as a specific in vivo marker of early microglial activation in a rat model of progressive dopaminergic degeneration
T Rodríguez-Chinchilla, A Quiroga-Varela… - European Journal of …, 2020 - Springer
Purpose To study the feasibility of the in vivo [18 F]-DPA-714 TSPO positron emission
tomography (PET) to detect glial activation in a rat model of progressive parkinsonism …
tomography (PET) to detect glial activation in a rat model of progressive parkinsonism …
Denoising of dynamic PET images using a multi-scale transform and non-local means filter
The quantification of positron emission tomography (PET) images requires a time activity
curve (TAC) to provide an accurate estimation of kinetic parameters. However, the low …
curve (TAC) to provide an accurate estimation of kinetic parameters. However, the low …
Minimally invasive quantification of cerebral P2X7R occupancy using dynamic [18F]JNJ-64413739 PET and MRA-driven image derived input function
N Mertens, ME Schmidt, A Hijzen… - Scientific Reports, 2021 - nature.com
Abstract [18F] JNJ-64413739 has been evaluated as PET-ligand for in vivo quantification of
purinergic receptor subtype 7 receptor (P2X7R) using Logan graphical analysis with a …
purinergic receptor subtype 7 receptor (P2X7R) using Logan graphical analysis with a …
Reliable quantification of 18F-GE-180 PET neuroinflammation studies using an individually scaled population-based input function or late tissue-to-blood ratio
R Buchert, M Dirks, C Schütze, F Wilke… - European journal of …, 2020 - Springer
Purpose Tracer kinetic modeling of tissue time activity curves and the individual input
function based on arterial blood sampling and metabolite correction is the gold standard for …
function based on arterial blood sampling and metabolite correction is the gold standard for …
Non-invasive estimation of [11C] PBR28 binding potential
Abstract [11 C] PBR28 is a PET radioligand used to estimate densities of the 18 kDa
translocator protein (TSPO) in vivo. Since there is no suitable reference region, arterial blood …
translocator protein (TSPO) in vivo. Since there is no suitable reference region, arterial blood …
Novel tracers and radionuclides in PET imaging
C Mason, GR Gimblet, SE Lapi… - Radiologic …, 2021 - radiologic.theclinics.com
This article first discusses many of the most prominent PET imaging agents in late preclinical
and early clinical development in oncology. These agents are intended to take advantage of …
and early clinical development in oncology. These agents are intended to take advantage of …