Extensive data have shown that Wnt/beta-catenin signaling is associated with various
disease pathologies, including an important role in tumorigenesis. Here, we review the …

Epigenetic modifications of chromatin play an important role in the regulation of gene
expression. KMT4/Dot1 is a conserved histone methyltransferase capable of methylating …

The progression to advanced stage cancer requires changes in many characteristics of a
cell. These changes are usually initiated through spontaneous mutation. As a result of these …

Wnt/β-catenin signaling plays a central role in development and is also involved in a diverse
array of diseases. β-Catenin activity is tightly regulated via a multiprotein complex that …

Acetylation of the lysine residues in histones and other DNA-binding proteins plays a major
role in regulation of eukaryotic gene expression. This process is controlled by histone …

The appendix gives rise to goblet cell carcinoids, which represent special carcinomas with
distinct biological and histological features. Their genetic background and molecular …

The Wnt pathway is a key regulator of embryonic development and stem cells, and its
aberrant activation is associated with human malignancies, most notably hepatocellular …

Background Whether myofibers increase with a pulsed-wave mode at particular
developmental stages or whether they augment evenly across developmental stages in …

Kinases play a critical role in regulating many cellular functions including development,
differentiation and proliferation. To date, over 518 proteins with kinase activity, comprising …

The PAF complex (PAFc) participates in various steps of the transcriptional process, from
initiation to termination, by interacting with and recruiting various proteins to the proper locus …