Hydrogels for RNA delivery

R Zhong, S Talebian, BB Mendes, G Wallace… - Nature materials, 2023 - nature.com
RNA-based therapeutics have shown tremendous promise in disease intervention at the
genetic level, and some have been approved for clinical use, including the recent COVID-19 …

Chemically modified biopolymers for the formation of biomedical hydrogels

VG Muir, JA Burdick - Chemical reviews, 2020 - ACS Publications
Biopolymers are natural polymers sourced from plants and animals, which include a variety
of polysaccharides and polypeptides. The inclusion of biopolymers into biomedical …

Development of innovative biomaterials and devices for the treatment of cardiovascular diseases

Y Wang, G Li, L Yang, R Luo, G Guo - Advanced Materials, 2022 - Wiley Online Library
Cardiovascular diseases have become the leading cause of death worldwide. The
increasing burden of cardiovascular diseases has become a major public health problem …

The current state and future directions of RNAi-based therapeutics

RL Setten, JJ Rossi, S Han - Nature reviews Drug discovery, 2019 - nature.com
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …

Recent advances in shear‐thinning and self‐healing hydrogels for biomedical applications

S Uman, A Dhand, JA Burdick - Journal of Applied Polymer …, 2020 - Wiley Online Library
Shear‐thinning and self‐healing hydrogels are being investigated in various biomedical
applications including drug delivery, tissue engineering, and 3D bioprinting. Such hydrogels …

Applications of π-π stacking interactions in the design of drug-delivery systems

WR Zhuang, Y Wang, PF Cui, L Xing, J Lee… - Journal of controlled …, 2019 - Elsevier
Noncovalent forces are of considerable importance in the formation of self-assembled drug-
delivery systems. In addition to non-destructively linking the delivery vehicle and guest drug …

Advances in Injectable and Self‐healing Polysaccharide Hydrogel Based on the Schiff Base Reaction

C Mo, L Xiang, Y Chen - Macromolecular rapid …, 2021 - Wiley Online Library
Injectable hydrogel possesses great application potential in disease treatment and tissue
engineering, but damage to gel often occurs due to the squeezing pressure from injection …

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

C Gong, J Tian, Z Wang, Y Gao, X Wu, X Ding… - Journal of …, 2019 - Springer
Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological
information between cells. However, Exo are limited in terms of their abilities to target …

Bioinspired Spatiotemporal Management toward RNA Therapies

Y Ma, S Li, X Lin, Y Chen - ACS nano, 2023 - ACS Publications
Ribonucleic acid (RNA)-based therapies have become an attractive topic in disease
intervention, especially with some that have been approved by the FDA such as the mRNA …

[HTML][HTML] The recent advances in scaffolds for integrated periodontal regeneration

HN Woo, YJ Cho, S Tarafder, CH Lee - Bioactive materials, 2021 - Elsevier
The periodontium is an integrated, functional unit of multiple tissues surrounding and
supporting the tooth, including but not limited to cementum (CM), periodontal ligament (PDL) …