Recent advances in mass spectrometry-based structural elucidation techniques

X Ma - Molecules, 2022 - mdpi.com
Mass spectrometry (MS) has become the central technique that is extensively used for the
analysis of molecular structures of unknown compounds in the gas phase. It manipulates the …

A Portable Reagent Inlet System Designed to Diminish the Impact of Air and Water to Ion–Molecule Reactions Studied in a Linear Quadrupole Ion Trap

E Feng, Y Fu, X Ma, RR Kotha, D Ding… - Journal of the …, 2022 - ACS Publications
A portable reagent inlet system for a linear quadrupole ion trap (LQIT) mass spectrometer
was designed to diminish the impact of air and water on gas-phase ion–molecule reactions …

Ultrahigh‐performance liquid chromatography Q‐Exactive‐Orbitrap mass spectrometry and molecular network analysis alongside network pharmacology to elucidate …

S Li, Z Liu, H Zeng, J Fu, M Sun, C Bao… - … in Mass Spectrometry, 2024 - Wiley Online Library
Rationale Huahong tablet, a commonly used clinical Chinese patent medicine, shows good
efficacy in treating pelvic inflammation and other gynaecological infectious diseases …

Chemical composition analysis of Qingyan dropping pills using ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight mass spectrometry

L Shu, H Qiu, Y He, S Zhang, J Qian… - Rapid …, 2024 - Wiley Online Library
Rationale This study developed a method for the rapid classification and identification of the
chemical composition of Qingyan dropping pills (QDP) to provide the theoretical basis and …

Modification of a Quadrupole/Orbitrap/Linear Quadrupole Ion Trap Tribrid Mass Spectrometer for Diagnostic Gas-Phase Ion–Molecule Reactions

Y Fu, CJ Brown, JT Johnson, BM Marsh… - Journal of the …, 2023 - ACS Publications
Tandem mass spectrometry based on diagnostic gas-phase ion–molecule reactions
represents a robust method for functional group identification in unknown compounds. To …

Differentiation of Protonated Sulfonate Esters from Isomeric Sulfite Esters and Sulfones by Gas-Phase Ion–Molecule Reactions Followed by Diagnostic Collision …

E Feng, X Ma, H Jiang, H Sheng, CE Rowell… - Analytical …, 2022 - ACS Publications
Sulfonate esters, a class of potentially mutagenic drug impurities, are strictly regulated in
pharmaceuticals. On the other hand, sulfite esters and sulfones, analogs of sulfonate esters …

Differentiation of the Aziridine Functionality from Related Functional Groups in Protonated Analytes by Using Selective Ion-Molecule Reactions Followed by Collision …

RO Anyaeche, KZ Alzarieni, R Kumar… - The Journal of …, 2023 - ACS Publications
Aziridines are commonly used as reagents for the synthesis of drug substances although
they are potentially mutagenic and genotoxic. Therefore, their unambiguous detection is …

Exploring and modeling the ion mobility spectrometry of perindopril: Example of protonation‐dissociation reactions in large molecules

H Douroudgari, H Bahrami, FM Valadi… - Journal of Mass …, 2022 - Wiley Online Library
The current research is constructed for considering the chemical ionization and dissociation
of perindopril in the positive mode of corona discharge ion mobility spectrometry. Four …