The synapsins: key actors of synapse function and plasticity
The synapsins are a family of neuronal phosphoproteins evolutionarily conserved in
invertebrate and vertebrate organisms. Their best-characterised function is to modulate …
invertebrate and vertebrate organisms. Their best-characterised function is to modulate …
A roadmap for precision medicine in the epilepsies
EpiPM Consortium - The Lancet Neurology, 2015 - Elsevier
Technological advances have paved the way for accelerated genomic discovery and are
bringing precision medicine clearly into view. Epilepsy research in particular is well suited to …
bringing precision medicine clearly into view. Epilepsy research in particular is well suited to …
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
Nature communications, 2018 - nature.com
The epilepsies affect around 65 million people worldwide and have a substantial missing
heritability component. We report a genome-wide mega-analysis involving 15,212 …
heritability component. We report a genome-wide mega-analysis involving 15,212 …
Identification of common variants associated with human hippocampal and intracranial volumes
Identifying genetic variants influencing human brain structures may reveal new biological
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …
[HTML][HTML] ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide
In this review, we discuss recent work by the ENIGMA Consortium (http://enigma. ini. usc.
edu)–a global alliance of over 500 scientists spread across 200 institutions in 35 countries …
edu)–a global alliance of over 500 scientists spread across 200 institutions in 35 countries …
Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms
F Alyu, M Dikmen - Acta neuropsychiatrica, 2017 - cambridge.org
ObjectiveEpilepsy is a chronic neurological disease characterised with seizures. The
aetiology of the most generalised epilepsies cannot be explicitly determined and the …
aetiology of the most generalised epilepsies cannot be explicitly determined and the …
BK channels in the central nervous system
Large conductance Ca 2+-and voltage-activated K+(BK) channels are widely distributed in
the postnatal central nervous system (CNS). BK channels play a pleiotropic role in …
the postnatal central nervous system (CNS). BK channels play a pleiotropic role in …
Large mammalian animal models of heart disease
Due to the biological complexity of the cardiovascular system, the animal model is an urgent
pre-clinical need to advance our knowledge of cardiovascular disease and to explore new …
pre-clinical need to advance our knowledge of cardiovascular disease and to explore new …
Genetic testing in the epilepsies—report of the ILAE Genetics Commission
In this report, the International League Against Epilepsy (ILAE) Genetics Commission
discusses essential issues to be considered with regard to clinical genetic testing in the …
discusses essential issues to be considered with regard to clinical genetic testing in the …
Navigating the channels and beyond: unravelling the genetics of the epilepsies
Genetic factors are now recognised to have an even more important role in epilepsies than
previously appreciated. Rare mendelian forms of epilepsy are now well recognised, and …
previously appreciated. Rare mendelian forms of epilepsy are now well recognised, and …