Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Abstract Purpose of Review Extracellular vesicles (EV), which include exosomes and
microvesicles, are membrane-bound particles shed by most cell types and are important …

Maintenance of skeletal health is tightly regulated by osteocytes, osteoblasts, and
osteoclasts via coordinated secretion of bone-derived factors, termed osteokines. Disruption …

Abstract Purpose of Review The role of bone-derived factors in regulation of skeletal muscle
function is an important emerging aspect of research into bone-muscle crosstalk …

Aromatase inhibitors (AIs) cause muscle weakness, bone loss, and joint pain in up to half of
cancer patients. Preclinical studies have demonstrated that increased osteoclastic bone …

We evaluated biochemical changes in skeletal muscle of women with breast cancer
initiating aromatase inhibitors (AI), including oxidation of ryanodine receptor RyR1 and loss …

Rotator cuff calcific tendinopathy and arthrofibrosis of the shoulder (adhesive capsulitis) are
debilitating musculoskeletal disorders that significantly impact joint function and impair …

Calcium plays central roles in numerous biological processes, thereby, its levels in the blood
are under strict control to maintain homeostatic balance and enable the proper functioning of …

Osteoporosis is a condition featured by bone mass loss and bone tissue microarchitectural
alterations due to impaired tissue homeostasis favoring excessive bone resorption versus …

Background: Although 80% of childhood acute lymphoblastic leukemia (ALL) cases are
cured with current treatment protocols, exposure to chemotherapeutics or radiation therapy …