Leukodystrophies comprise a large group of rare genetic disorders primarily affecting CNS
white matter. Historically, the diagnostic process was slow and patient prognosis regarded …

Krabbe disease (globoid cell leukodystrophy) is a lysosomal storage disease (LSD)
characterized by progressive and profound demyelination. Infantile, juvenile and adult-onset …

Mesenchymal stromal stem cells (MSCs) isolated from adult tissues offer tangible potential
for regenerative medicine, given their feasibility for autologous transplantation. MSC …

Background Mesenchymal stem/progenitor cells (MSC) have shown beneficial effects in
many models of disease in part by modulating excessive inflammatory and immune …

Lysosomal storage disorders (LSDs) are a heterogeneous group of inherited diseases with
a collective frequency of∼ 1 in 7000 births, resulting from the deficiency in one or more …

Globoid cell leukodystrophy (GLD) is a lysosomal storage disease caused by deficient
activity of β-galactocerebrosidase (GALC). The infantile forms manifest with rapid and …

There is significant interest in the use of mesenchymal stem cells (MSCs) as a potential
therapeutic modality in disease and disorder, particularly those with an inflammation-based …

Cognitive aging is a leading public health concern with the increasing aging population, but
there is still lack of specific interventions directed against it. Recent studies have shown that …

Although neuropathic pain is one of the most intractable diseases, recent studies indicate
that systemic or local injection of bone marrow stromal cells (BMSCs) decreases pro …

Globoid cell leukodystrophy (GLD) is an inherited lysosomal storage disease caused by β-
galactocerebrosidase (GALC) deficiency. Gene therapy (GT) should provide rapid, extensive …