Piperazine and homopiperazine are well-studied heterocycles in drug design that have
found gainful application as scaffolds and terminal elements and for enhancing the aqueous …

The drug resistance and low specificity of current available chemotherapeutics to cancer
cells are the main reasons responsible for the failure of cancer chemotherapy and remain …

Simple Summary Cancer is the leading cause of death worldwide and responsible for killing
approximately 10 million people per year. Fused heterocyclic ring systems such as …

The piperazine scaffold is a privileged structure frequently found in biologically active
compounds. Piperazine nucleus is found in many marketed drugs in the realm of …

DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication,
recombination, and repair. Despite the popular applications of topo II inhibitors in cancer …

Medicinal chemistry is a science applied to the search and discovery of new therapeutic
agents for the treatment of various diseases. Therefore, promising structures have been …

Depression is the single largest contributor to global disability with a huge economic and
social burden on the world. There are a number of antidepressant drugs on the market, but …

Pentacyclic triterpenoids are well-known phytochemicals with various biological activities
commonly found in plants as secondary metabolites. The wide range of biological activities …

Avapritinib is a complex molecule with many heterocyclic rings developed for the treatment
of advanced PDGFRA D842V-mutant gastrointestinal stromal tumours. The manuscripts …

Piperazine, is privileged six membered nitrogen containing heterocyclic ring also known as
1, 4-Diazacyclohexane. Consequently, piperazine is a versatile medicinally important …