HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation
MA Checkley, BG Luttge, EO Freed - Journal of molecular biology, 2011 - Elsevier
The HIV-1 envelope (Env) glycoproteins play an essential role in the virus replication cycle
by mediating the fusion between viral and cellular membranes during the entry process. The …
by mediating the fusion between viral and cellular membranes during the entry process. The …
Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme
JM White, SE Delos, M Brecher… - Critical reviews in …, 2008 - Taylor & Francis
Recent work has identified three distinct classes of viral membrane fusion proteins based on
structural criteria. In addition, there are at least four distinct mechanisms by which viral fusion …
structural criteria. In addition, there are at least four distinct mechanisms by which viral fusion …
A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP. 664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing …
RW Sanders, R Derking, A Cupo, JP Julien… - PLoS …, 2013 - journals.plos.org
A desirable but as yet unachieved property of a human immunodeficiency virus type 1 (HIV-
1) vaccine candidate is the ability to induce broadly neutralizing antibodies (bNAbs). One …
1) vaccine candidate is the ability to induce broadly neutralizing antibodies (bNAbs). One …
Insights on the mutational landscape of the SARS-CoV-2 Omicron variant receptor-binding domain
The Omicron variant features enhanced transmissibility and antibody escape. Here, we
describe the Omicron receptor-binding domain (RBD) mutational landscape using amino …
describe the Omicron receptor-binding domain (RBD) mutational landscape using amino …
Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses
Cell-free human immunodeficiency virus type 1 (HIV-1) can initiate infections, but contact
between infected and uninfected T cells can enhance viral spread through intercellular …
between infected and uninfected T cells can enhance viral spread through intercellular …
Virus evolution: insights from an experimental approach
SF Elena, R Sanjuán - Annu. Rev. Ecol. Evol. Syst., 2007 - annualreviews.org
Viruses represent a serious problem faced by human and veterinary medicine and
agronomy. New viruses are constantly emerging while old ones evolve and challenge the …
agronomy. New viruses are constantly emerging while old ones evolve and challenge the …
Clustering and mobility of HIV-1 Env at viral assembly sites predict its propensity to induce cell-cell fusion
NH Roy, J Chan, M Lambelé, M Thali - Journal of virology, 2013 - Am Soc Microbiol
ABSTRACT HIV-1 Env mediates virus attachment to and fusion with target cell membranes,
and yet, while Env is still situated at the plasma membrane of the producer cell and before its …
and yet, while Env is still situated at the plasma membrane of the producer cell and before its …
Reduced potency and incomplete neutralization of broadly neutralizing antibodies against cell-to-cell transmission of HIV-1 with transmitted founder Envs
H Li, C Zony, P Chen, BK Chen - Journal of virology, 2017 - Am Soc Microbiol
Broadly neutralizing antibodies (bNAbs) have been isolated from HIV-1 patients and can
potently block infection of a wide spectrum of HIV-1 subtypes. These antibodies define …
potently block infection of a wide spectrum of HIV-1 subtypes. These antibodies define …
The lipid membrane of HIV-1 stabilizes the viral envelope glycoproteins and modulates their sensitivity to antibody neutralization
H Salimi, J Johnson, MG Flores, MS Zhang… - Journal of Biological …, 2020 - ASBMB
The envelope glycoproteins (Envs) of HIV-1 are embedded in the cholesterol-rich lipid
membrane of the virus. Chemical depletion of cholesterol from HIV-1 particles inactivates …
membrane of the virus. Chemical depletion of cholesterol from HIV-1 particles inactivates …
[HTML][HTML] Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India
SS Kulkarni, A Lapedes, H Tang, S Gnanakaran… - Virology, 2009 - Elsevier
Little is known about the neutralization properties of HIV-1 in India to optimally design and
test vaccines. For this reason, a functional Env clone was obtained from each of ten newly …
test vaccines. For this reason, a functional Env clone was obtained from each of ten newly …