Pancreatic ductal adenocarcinoma (PDAC), which accounts for more than 90% of all
pancreatic tumours, is a devastating malignancy with an extremely poor prognosis, as …

Neuroendocrine neoplasms constitute a diverse group of tumors that derive from the
sensory and secretory neuroendocrine cells and predominantly arise within the pulmonary …

Contrast-enhanced computed tomography (CT) of the neck-thorax-abdomen and pelvis,
including 3-phase examination of the liver, constitutes the basic imaging for primary …

Purpose We investigated the global gene expression in a large panel of pancreatic
endocrine tumors (PETs) aimed at identifying new potential targets for therapy and …

Pancreatic endocrine neoplasms (PETs) are uncommon tumors with an annual incidence
less than 1 per 100,000 persons per year in the general population. PETs that produce …

Learning Objectives Assess the basic aspects of PNET tumor biology, pathogenesis, and
classification. Explain the epidemiology and evaluate the prognosis of PNET patients …

Acidic tissue microenvironment contributes to tumor progression via multiple effects
including the activation of angiogenic factors and proteases, reduced cell-cell adhesion …

Seeking to assess the representative and instructive value of an engineered mouse model
of pancreatic neuroendocrine tumors (PanNET) for its cognate human cancer, we profiled …

Background Tumor hypoxia is an independent prognostic factor associated with poor patient
survival. Emerging evidence suggests that hypoxia can potentially maintain or enhance the …

Hypoxia is a characteristic of many solid tumors and an adverse prognostic factor for
treatment outcome. Hypoxia increases the expression of carbonic anhydrase IX (CAIX), an …