Pathogenic microorganisms encounter a variety of environmental stresses following
infection of their respective hosts. Mycobacterium tuberculosis, the etiological agent of …

Two‐component regulatory systems (2CRSs) are key players in bacterial responses to
changing environments (1, 2). These systems act to integrate multiple stimuli into …

Mycobacteria owe their success as pathogens to their ability to persist for long periods within
host cells in asymptomatic, latent forms before they opportunistically switch to the virulent …

The virulence of Mycobacterium tuberculosis depends on the ability of the bacilli to switch
between replicative (growth) and non‐replicative (dormancy) states in response to host …

Background Novel therapeutics are urgently needed to control tuberculosis (TB).
Thioridazine (THZ) is a candidate for the therapy of multidrug and extensively drug-resistant …

The DNA damage response is crucial for bacterial survival. The transcriptional repressor
LexA is a key component of the SOS response, the main mechanism for the regulation of …

The ESX-1 secretion system exports the immunomodulatory protein ESAT-6 and other
proteins important in the pathogenesis of Mycobacterium tuberculosis. Components and …

ABSTRACT The Mycobacterium tuberculosis prrA-prrB (Rv0903c-Rv0902c) two-component
regulatory system is expressed during intracellular growth in human macrophages and is …

Mycolic acids are the signature lipid of mycobacteria and constitute an important physical
component of the cell wall, a target of mycobacterium-specific antibiotics and a mediator of …

The regulatory mechanisms that control the ESX-1 secretion system, a key player in the
pathogenesis of Mycobacterium tuberculosis, have not been fully elucidated. However …