GDNF, NGF and BDNF as therapeutic options for neurodegeneration

SJ Allen, JJ Watson, DK Shoemark, NU Barua… - Pharmacology & …, 2013 - Elsevier
Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor
(NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival …

[HTML][HTML] BDNF polymorphism: a review of its diagnostic and clinical relevance in neurodegenerative disorders

T Shen, Y You, C Joseph, M Mirzaei… - Aging and …, 2018 - ncbi.nlm.nih.gov
Brain-derived neurotrophic factor (BDNF) has a unique role in the neuronal development,
differentiation, and survival in the developing and adult nervous system. A common single …

[PDF][PDF] Brain-derived neurotrophic factor and its clinical implications

S Bathina, UN Das - Archives of medical science, 2015 - termedia.pl
Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and
growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity …

DNA methylation of the BDNF gene and its relevance to psychiatric disorders

T Ikegame, M Bundo, Y Murata, K Kasai… - Journal of human …, 2013 - nature.com
Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor, which is important for
neuronal survival, development and synaptic plasticity. Accumulating evidence suggests …

Wheel running and environmental enrichment differentially modify exon‐specific BDNF expression in the hippocampus of wild‐type and pre‐motor symptomatic male …

MS Zajac, TYC Pang, N Wong, B Weinrich… - …, 2010 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is an essential neurotrophin and regulation of its
expression is complex due to multiple 5′ untranslated exons which are separately spliced …

Sigma‐1 receptor chaperones regulate the secretion of brain‐derived neurotrophic factor

M Fujimoto, T Hayashi, R Urfer, S Mita, TP Su - Synapse, 2012 - Wiley Online Library
Abstract The sigma‐1 receptor (Sig‐1R) is a novel endoplasmic reticulum (ER) molecular
chaperone that regulates protein folding and degradation. The Sig‐1R activation by agonists …

Neurotrophins and their role in the cochlea

D Ramekers, H Versnel, W Grolman, SFL Klis - Hearing research, 2012 - Elsevier
Spiral ganglion cell (SGC) degeneration following hair cell loss can be prevented by
administration of exogenous neurotrophic factors. Many of these neurotrophic factors, in …

Emerging biomarkers of multiple sclerosis in the blood and the CSF: a focus on neurofilaments and therapeutic considerations

T Biernacki, Z Kokas, D Sandi, J Füvesi… - International Journal of …, 2022 - mdpi.com
Introduction: Multiple Sclerosis (MS) is the most common immune-mediated chronic
neurodegenerative disease of the central nervous system (CNS) affecting young people …

An overview of neuroblastoma cell lineage phenotypes and in vitro models

S Campos Cogo… - Experimental …, 2020 - journals.sagepub.com
This review was conducted to present the main neuroblastoma (NB) clinical characteristics
and the most common genetic alterations present in these pediatric tumors, highlighting their …

Acute stress alters transcript expression pattern and reduces processing of proBDNF to mature BDNF in Dicentrarchus labrax

C Tognoli, F Rossi, F Di Cola, G Baj, E Tongiorgi… - BMC neuroscience, 2010 - Springer
Background Stress involves alterations of brain functioning that may precipitate to mood
disorders. The neurotrophin Brain Derived Neurotrophic Factor (BDNF) has recently been …