Patients suffering from iron overload can experience serious complications. In such patients,
various organs, such as endocrine glands and liver, can be damaged. Although iron is a …

Chelation therapy is the preferred medical treatment for reducing the toxic effects of metals.
Chelating agents are capable of binding to toxic metal ions to form complex structures which …

Iron-chelation therapy has its origins in the treatment of iron-overload syndromes. For many
years, the standard for this purpose has been deferoxamine. Recently, considerable …

Hydroxamic acids, RCC (O) N (RN) OH (RC= alkyl/aryl; RN= alkyl/aryl or H), coordinate a
wide variety of transition metal ions predominantly as the monoanionic hydroxamato or …

Background In thalassemia major (TM), severe cardiac siderosis can be treated by
continuous parenteral deferoxamine, but poor compliance, complications and deaths occur …

RASopathies are a family of developmental disorders that share germline mutations in the
components of the RAS-MAPK pathway leading to dysregulated signalling. A high …

Iron chelation: an update : Current Opinion in Hematology Iron chelation: an update :
Current Opinion in Hematology Log in or Register Subscribe to journalSubscribe Get new …

Recently introduced chelation regimens that combine deferoxamine (DFO) and deferiprone
have been shown to have greater efficacy in promoting iron excretion than either chelator …

1Department of Haematology, Barts and the London School of Medicine and Dentistry,
London UK; 2Department of Biostatistics, City University, London, UK; 3Thalassaemia …

Purpose To investigate the correlation between the degree of hepatic, splenic, pancreatic,
vertebral bone marrow (VBM), and myocardial siderosis, as expressed by relaxation rate …