Shared mechanisms for cognitive impairment and physical frailty: a model for complex systems

L Sargent, M Nalls, EJ Amella… - … Research & Clinical …, 2020 - Wiley Online Library
Introduction We describe findings from a large study that provide empirical support for the
emerging construct of cognitive frailty and put forth a theoretical framework that may …

Unifying considerations and evidence of macrophage activation mosaicism through human CSF1R and M1/M2 genes

F Orsenigo, A Stewart, CP Hammer, E Clarke… - Cell Reports, 2024 - cell.com
Addressing the mononuclear phagocyte system (MPS) and macrophage M1/M2 activation is
important in diagnosing hematological disorders and inflammatory pathologies and …

[HTML][HTML] Elucidating the Mechanisms of Leukemogenesis Driven By FBXO11 Depletion

A Mo, LYT Chang, G Duns, X Wang, G Morin, T Lau… - Blood, 2021 - Elsevier
Mutations in SKP1 and CUL1 (Zhang et. al. Oncol Lett 2018), which encode components of
the SKP1-CUL1-F-BOX (SCF) ubiquitin E3-ligase complex, have previously been reported …