Neuronal communication crucially relies on exocytosis of neurotransmitters from synaptic
vesicles (SVs) which are clustered at synapses. To ensure reliable neurotransmitter release …

Protein-protein and protein-RNA interactions are essential for cell function and survival.
These interactions facilitate the formation of ribonucleoprotein complexes and biomolecular …

Genetic variation at the transmembrane protein 106B gene (TMEM106B) has been linked to
risk of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) through an …

Neuronal activity causes use-dependent decline in protein function. However, it is unclear
how this is coupled to local quality control mechanisms. We show in Drosophila that the …

Compensatory endocytosis keeps the membrane surface area of secretory cells constant
following exocytosis. At chemical synapses, clathrin-independent ultrafast endocytosis …

Endocytic dynamins self-assemble into helical scaffolds and utilize energy from GTP
hydrolysis to constrict and sever tubular membranous necks of budded endocytic …

Gastrointestinal diseases exert a profound impact on global health, leading to millions of
healthcare interventions and a significant number of fatalities annually. This, coupled with …

With an essential role in nearly every physiological process and disease state, trafficking
vesicles are fundamental to cell biology. Canonical understanding of membrane traffic has …

Abstract α-Synuclein (αSYN), a pivotal synaptic protein implicated in synucleinopathies such
as Parkinson's disease and Lewy body dementia, undergoes protein phase separation. We …

The microtubule-associated protein tau is an intrinsically disordered protein containing a few
short and transient secondary structures. Tau physiologically associates with microtubules …