Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides
and nucleosides. Tri-and diphosphonucleotides are released in physiological and …

Macrophages comprise a phenotypically and functionally diverse group of hematopoietic
cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity. To …

Cutaneous leishmaniases have persisted for centuries as chronically disfiguring parasitic
infections affecting millions of people across the subtropics. Symptoms range from the more …

Extracellular nucleotides are danger signals involved in recognition and control of
intracellular pathogens. They are an important component of the innate immune response …

The Trypanosomatidae family includes the genera Trypanosoma and Leishmania,
protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and …

Leishmaniasis is a neglected tropical disease affecting millions of individuals worldwide.
P2X7 receptor has been linked to the elimination of Leishmania amazonensis. Biological …

Immune cells of myeloid origin show robust expression of ATP-gated P2X7 receptors, two-
transmembrane ion channels permeable to Na+, K+, and Ca 2+. Receptor activation …

Purinergic signalling is an evolutionarily conserved signalling pathway mediated by
extracellular nucleotides and nucleosides. Tri-and diphosphonucleotides released from host …

ATP is an important signaling molecule in the immune system, and it is able to bind the
P2X7 purinergic receptor. Recently, our group showed that ATP-treated macrophages …

The purinergic P2Y receptors comprise eight G-coupled receptor (GPCR) subtypes already
identified (P2Y 1, P2Y 2, P2Y 4, P2Y 6, P2Y 11, P2Y 12–14). P2Y receptor physiological …