Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are the most abundant
phospholipids in all mammalian cell membranes. In the 1950s, Eugene Kennedy and co …

Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which
is the most common form of liver disease and is present in up to∼ 70% of individuals who …

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain
without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) …

High-fat diet (HFD) decreases insulin sensitivity. How high-fat diet causes insulin resistance
is largely unknown. Here, we show that lean mice become insulin resistant after being …

As the predominant type of chronic liver disease, the growing prevalence of nonalcoholic
fatty liver disease (NAFLD) has become a concern worldwide. Although obesity plays the …

Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the
mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 …

Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance
and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and …

The endoplasmic reticulum (ER) is the main site of protein and lipid synthesis, membrane
biogenesis, xenobiotic detoxification and cellular calcium storage, and perturbation of ER …

Choline influences liver function, and the dietary requirement for this nutrient varies
depending on an individual's genotype and estrogen status. Understanding these individual …

Sterol regulatory element-binding proteins (SREBPs) activate genes involved in the
synthesis and trafficking of cholesterol and other lipids and are critical for maintaining lipid …