The B vitamins folic acid, vitamin B12 and B6 are essential for neuronal function, and severe
deficiencies have been linked to increased risk of neurodevelopmental disorders …

Aripiprazole was the first antipsychotic developed to possess agonist properties at
dopamine D2 autoreceptors, a groundbreaking strategy that presented a new vista for …

Antipsychotic response in schizophrenia is a complex, multifactorial trait influenced by
pharmacogenetic factors. With genetic studies thus far providing little biological insight or …

Previous studies suggest that elevated blood homocysteine levels and the
methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism are risk factors for …

Dopamine is important to learning and plasticity. Dopaminergic drugs are the focus of many
therapies targeting the motor system, where high inter-individual differences in response are …

Genetic polymorphism in olanzapine-metabolizing enzymes, transporters and drug targets is
associated with alterations in safety and efficacy. The aim of this systematic review is to …

Introduction: 5-Hydroxytryptamine 2A receptors (5-HT2A-Rs) are widely expressed in the
brain and have been implicated in mood and behavior. Based on the use of atypical …

Mental illness represents a major health issue both at the individual and at the
socioeconomical level. This is partly due to the current suboptimal treatment options …

Background: The catechol-O-methyltransferase (COMT) enzyme plays a crucial role in
dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with …

Schizophrenia (SCZ) is a complex psychiatric disorder of multifactorial origin, in which both
genetic and environmental factors have an impact on its onset, course, and outcome. Large …