Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical
applications have received much attention from the global scientific community in an …

Bone is a regenerative organ characterized by self-renewal ability. Indeed, it is a very
dynamic tissue subjected to continuous remodeling in order to preserve its structure and …

Administration of exosomes is considered an attractive cell-free approach to skeletal repair
and pathological disease treatment. However, poor yield for the production technique and …

Co-culturing of cells in in vitro tissue models is widely used to study how they interact with
each other. These models serve to represent a variety of processes in the human body such …

The regeneration of bone defects in patients with diabetes mellitus (DM) is remarkably
impaired by hyperglycemia and over-expressed proinflammatory cytokines, proteinases …

Mesenchymal stem cell-based therapy has become an effective therapeutic approach for
bone regeneration. However, there are still limitations in successful clinical translation …

As bone grafts become more commonly needed by patients and as donors become scarcer,
acellularized bone grafts (ABGs) are becoming more popular for restorative purposes. While …

Mesenchymal stem cell-based therapies are promising tools for bone tissue regeneration.
However, tracking cells and maintaining them in the site of injury is difficult. A potential …

Background Exosomes derived from the bone marrow mesenchymal stem cell (MSC) have
shown great potential in spinal cord injury (SCI) treatment. This research was designed to …

Cellular therapy aims to replace damaged resident cells by restoring cellular and molecular
environments suitable for tissue repair and regeneration. Among several candidates …