Protein aggregation–mechanisms, detection, and control
W Wang, CJ Roberts - International journal of pharmaceutics, 2018 - Elsevier
Protein aggregation has been recognized as one of the major challenges in the
development and commercialization of successful protein-based drug products because of …
development and commercialization of successful protein-based drug products because of …
Science and art of protein formulation development
W Wang, S Ohtake - International journal of pharmaceutics, 2019 - Elsevier
Protein pharmaceuticals have become a significant class of marketed drug products and are
expected to grow steadily over the next decade. Development of a commercial protein …
expected to grow steadily over the next decade. Development of a commercial protein …
Immunoglobulin light chain amyloid aggregation
LM Blancas-Mejia, P Misra, CJ Dick… - Chemical …, 2018 - pubs.rsc.org
Light chain (AL) amyloidosis is a devastating, complex, and incurable protein misfolding
disease. It is characterized by an abnormal proliferation of plasma cells (fully differentiated B …
disease. It is characterized by an abnormal proliferation of plasma cells (fully differentiated B …
Structural mapping of oligomeric intermediates in an amyloid assembly pathway
TK Karamanos, MP Jackson, AN Calabrese… - Elife, 2019 - elifesciences.org
Transient oligomers are commonly formed in the early stages of amyloid assembly.
Determining the structure (s) of these species and defining their role (s) in assembly is key to …
Determining the structure (s) of these species and defining their role (s) in assembly is key to …
Understanding AL amyloidosis with a little help from in vivo models
G Martinez-Rivas, S Bender, C Sirac - Frontiers in Immunology, 2022 - frontiersin.org
Monoclonal immunoglobulin (Ig) light chain amyloidosis (AL) is a rare but severe disease
that may occur when a B or plasma cell clone secretes an excess of free Ig light chains …
that may occur when a B or plasma cell clone secretes an excess of free Ig light chains …
Animal models of monoclonal immunoglobulin-related renal diseases
The renal deposition of monoclonal immunoglobulins can cause severe renal complications
in patients with B cell and plasma cell lymphoproliferative disorders. The overproduction of a …
in patients with B cell and plasma cell lymphoproliferative disorders. The overproduction of a …
Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers
N Kedia, K Arhzaouy, SK Pittman… - Proceedings of the …, 2019 - National Acad Sciences
Desmin-associated myofibrillar myopathy (MFM) has pathologic similarities to
neurodegeneration-associated protein aggregate diseases. Desmin is an abundant muscle …
neurodegeneration-associated protein aggregate diseases. Desmin is an abundant muscle …
The molecular lifecycle of amyloid–Mechanism of assembly, mesoscopic organisation, polymorphism, suprastructures, and biological consequences
The formation of a diverse range of amyloid structures from normally soluble proteins and
peptides is a hallmark of devastating human disorders as well as biological functions. The …
peptides is a hallmark of devastating human disorders as well as biological functions. The …
Design, synthesis, and characterization of protein origami based on self-assembly of a brick and staple artificial protein pair
L Moreaud, S Viollet, A Urvoas… - Proceedings of the …, 2023 - National Acad Sciences
A versatile strategy to create an inducible protein assembly with predefined geometry is
demonstrated. The assembly is triggered by a binding protein that staples two identical …
demonstrated. The assembly is triggered by a binding protein that staples two identical …
Mechanistic insights into the early events in the aggregation of immunoglobulin light chains
Little is known about the mechanism of amyloid assembly in immunoglobulin light chain (AL)
amyloidosis, in contrast to other amyloid diseases. Early events in the aggregation pathway …
amyloidosis, in contrast to other amyloid diseases. Early events in the aggregation pathway …