Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises
three highly homologous members known as PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) …

Recognition of pathogen‐associated molecular signatures is critically important in proper
activation of the immune system. The toll‐like receptor (TLR) signaling network is …

We describe here a new component of the phosphatidylinositol 3‐kinase/Akt signaling
pathway that directly impacts mitochondria. Akt (protein kinase B) was shown for the first …

The mammalian target of rapamycin (mTOR) is part of two distinct complexes, mTORC1,
containing raptor and mLST8, and mTORC2, containing rictor, mLST8 and sin1. Although …

Osteoporosis is among the most devastating side effects of glucocorticoid (GC) therapy for
the management of inflammatory and auto-immune diseases. Evidence from both humans …

We have demonstrated that T3 increases the expression of ZAKI-4α, an endogenous
calcineurin inhibitor. In this study we characterized a T3-dependent signaling cascade …

Loss of phosphatase and tensin homolog (PTEN) and amplification of the epidermal growth
factor receptor (EGFR) gene contribute to the progression of gliomas. As downstream targets …

Akt is involved in the regulation of diverse cellular functions such as cell proliferation, energy
metabolism, and apoptosis. Although three Akt isoforms are known, the function of each …

The signalling components upstream and downstream of the protein kinase mammalian
target of rapamycin (mTOR) are frequently altered in a wide variety of human diseases …

Identification of specific genes or signaling pathways involved in development of melanoma
could lead to new therapies that target and correct these defects. Recent studies have …