Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance

N Erin, J Grahovac, A Brozovic, T Efferth - Drug Resistance Updates, 2020 - Elsevier
It is well established that multifactorial drug resistance hinders successful cancer treatment.
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …

Interleukin-6: a masterplayer in the cytokine network

P Uciechowski, W Dempke - Oncology, 2020 - karger.com
Abstract Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the
expression of a variety of proteins responsible for acute inflammation, and plays an …

[HTML][HTML] The significant role of interleukin-6 and its signaling pathway in the immunopathogenesis and treatment of breast cancer

A Masjedi, V Hashemi, M Hojjat-Farsangi… - Biomedicine & …, 2018 - Elsevier
Despite remarkable improvements in cancer treatment approaches, breast cancer is still the
main cause of cancer-related death in women. Its principal cause is the resistance of the …

IL-6/STAT3 is a promising therapeutic target for hepatocellular carcinoma

J Xu, H Lin, G Wu, M Zhu, M Li - Frontiers in oncology, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is a common malignant tumor of which the occurrence and
development, the tumorigenicity of HCC is involving in multistep and multifactor interactions …

The PI3K/AKT signaling pathway in cancer: Molecular mechanisms and possible therapeutic interventions

MR Khezri, R Jafari, K Yousefi, NM Zolbanin - Experimental and molecular …, 2022 - Elsevier
The human body consists of countless cells with the possibility of excessive and
uncontrolled proliferation under certain dysregulated circumstances that could cause …

The immune-microenvironment confers chemoresistance of colorectal cancer through macrophage-derived IL6

Y Yin, S Yao, Y Hu, Y Feng, M Li, Z Bian, J Zhang… - Clinical Cancer …, 2017 - AACR
Abstract Purpose: Tumor-associated macrophages (TAMs) are frequently associated with
poor prognosis in human cancers. However, the effects of TAMs in colorectal cancer are …

The strategies to cure cancer patients by eradicating cancer stem-like cells

Y Mai, J Su, C Yang, C Xia, L Fu - Molecular Cancer, 2023 - Springer
Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …

Curcumin: An effective inhibitor of interleukin-6

M Ghandadi, A Sahebkar - Current pharmaceutical design, 2017 - ingentaconnect.com
Curcumin is apolyphenolic cominflammatory effects of curcumin. Moreover, curcumin can be
considered as potential therapy against IL-6 involvepound found in the dietary spice …

Exosome-derived miR-25-3p and miR-92a-3p stimulate liposarcoma progression

L Casadei, F Calore, CJ Creighton, M Guescini, K Batte… - Cancer research, 2017 - AACR
Despite the development of combined modality treatments against liposarcoma in recent
years, a significant proportion of patients respond only modestly to such approaches …

Therapeutic influence on important targets associated with chronic inflammation and oxidative stress in cancer treatment

M Neganova, J Liu, Y Aleksandrova, S Klochkov, R Fan - Cancers, 2021 - mdpi.com
Simple Summary There is no doubt that the need for new effective methods of cancer
treatment remains challenging, as cancer is the second cause of death based on the …