Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain
The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …
Emerging targets in neuroinflammation-driven chronic pain
Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …
and have limited success in controlling disease progression. Accumulating evidence …
Pathological pain and the neuroimmune interface
Reciprocal signalling between immunocompetent cells in the central nervous system (CNS)
has emerged as a key phenomenon underpinning pathological and chronic pain …
has emerged as a key phenomenon underpinning pathological and chronic pain …
Glia and pain: is chronic pain a gliopathy?
Activation of glial cells and neuro–glial interactions are emerging as key mechanisms
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for …
F Bachelerie, A Ben-Baruch, AM Burkhardt… - Pharmacological …, 2014 - Elsevier
Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …
Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation
PM Grace, KA Strand, EL Galer… - Proceedings of the …, 2016 - National Acad Sciences
Opioid use for pain management has dramatically increased, with little assessment of
potential pathophysiological consequences for the primary pain condition. Here, a short …
potential pathophysiological consequences for the primary pain condition. Here, a short …
Repertoire of microglial and macrophage responses after spinal cord injury
Macrophages from the peripheral circulation and those derived from resident microglia are
among the main effector cells of the inflammatory response that follows spinal cord trauma …
among the main effector cells of the inflammatory response that follows spinal cord trauma …
Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement
AL Kalinski, C Yoon, LD Huffman, PC Duncker… - elife, 2020 - elifesciences.org
Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized
dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6Chigh monocytes …
dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6Chigh monocytes …
Microglia during development and aging
GJ Harry - Pharmacology & therapeutics, 2013 - Elsevier
Microglia are critical nervous system-specific cells influencing brain development,
maintenance of the neural environment, response to injury, and repair. They contribute to …
maintenance of the neural environment, response to injury, and repair. They contribute to …