EGFR is a potential dual molecular target for cancer and Alzheimer's disease

HJ Choi, YJ Jeong, J Kim, HS Hoe - Frontiers in Pharmacology, 2023 - frontiersin.org
Many researchers are attempting to identify drugs that can be repurposed as effective
therapies for Alzheimer's disease (AD). Several recent studies have highlighted epidermal …

Kinases control of regulated cell death revealing druggable targets for Parkinson's disease

HM Mansour, AF Mohamed, AS El-Khatib… - Ageing Research …, 2023 - Elsevier
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in the
world. Motor impairment seen in PD is associated with dopaminergic neurotoxicity in the …

SARS-CoV-2 infection increases the gene expression profile for Alzheimer's disease risk

R Green, K Mayilsamy, AR McGill, TE Martinez… - … Therapy-Methods & …, 2022 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic has caused over 600,000,000
infections globally thus far. Up to 30% of individuals with mild to severe disease develop …

Pazopanib ameliorates rotenone-induced Parkinsonism in rats by suppressing multiple regulated cell death mechanisms

HM Mansour, AF Mohamed, MM Khattab… - Food and Chemical …, 2023 - Elsevier
Parkinson's disease (PD) is characterized by motor impairments and progressive
dopaminergic neuronal death in the substantia nigra (SN). Recently, the involvement of …

Histone acetylation in an Alzheimer's disease cell model promotes homeostatic amyloid-reducing pathways

DC Xu, H Sas-Nowosielska, G Donahue… - Acta Neuropathologica …, 2024 - Springer
Alzheimer's Disease (AD) is a disorder characterized by cognitive decline,
neurodegeneration, and accumulation of amyloid plaques and tau neurofibrillary tangles in …

Unraveling the intercellular communication disruption and key pathways in Alzheimer's disease: an integrative study of single-nucleus transcriptomes and genetic …

A Liu, BS Fernandes, C Citu, Z Zhao - Alzheimer's Research & Therapy, 2024 - Springer
Background Recently, single-nucleus RNA-seq (snRNA-seq) analyses have revealed
important cellular and functional features of Alzheimer's disease (AD), a prevalent …

[PDF][PDF] Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes

A Haglund, V Zuber, M Abouzeid, Y Yang, JH Ko… - Nature Genetics, 2025 - nature.com
Gene expression quantitative trait loci are widely used to infer relationships between genes
and central nervous system (CNS) phenotypes; however, the effect of brain disease on …

Acanthopanax senticosus improves cognitive impairment in Alzheimer's disease by promoting the phosphorylation of the MAPK signaling pathway

Z Zhang, Y Wu, D Shi, C Jiang, H Cao, F Jiang… - Frontiers in …, 2024 - frontiersin.org
Background Acanthopanax senticosus (AS) can improve sleep, enhance memory, and
reduce fatigue and is considered as an effective drug for Alzheimer's disease (AD). The …

Design, synthesis and bioevaluation of 1, 2, 4-thiadiazolidine-3, 5-dione derivatives as potential GSK-3β inhibitors for the treatment of Alzheimer's disease

Y Dong, J Lu, S Zhang, L Chen, J Wen, F Wang… - Bioorganic …, 2023 - Elsevier
Tideglusib is a non-competitive GSK-3β inhibitor which contain 1, 2, 4-thiadiazolidine-3, 5-
dione moiety, and now mainly used for progressive supranuclear palsy due to the lack of …

Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease

A Muraleedharan, SK Ray - Brain Sciences, 2024 - mdpi.com
There are approximately 24 million cases of Alzheimer's disease (AD) worldwide, and the
number of cases is expected to increase four-fold by 2050. AD is a neurodegenerative …