Interleukin-1 (IL-1) is the prototypical inflammatory cytokine: two distinct ligands (IL-1α and IL-
1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a myriad of secondary inflammatory …

Abstract Interleukin-1 (IL-1) is a highly active pro-inflammatory cytokine that lowers pain
thresholds and damages tissues. Monotherapy blocking IL-1 activity in autoinflammatory …

Abstract Background Familial Mediterranean fever, mevalonate kinase deficiency (also
known as the hyperimmunoglobulinemia D syndrome), and the tumor necrosis factor …

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory
disease, but many rheumatologists are not well acquainted with its management. The …

An expanding spectrum of acute and chronic non‐infectious inflammatory diseases is
uniquely responsive to IL‐1β neutralization. IL‐1β‐mediated diseases are often called “auto …

Objective To evaluate the response to treatment of autoinflammatory diseases from an
international registry and an up-to-date literature review. Methods The response to treatment …

The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

Monogenic autoinflammatory syndromes present with excessive systemic inflammation
including fever, rashes, arthritis, and organ-specific inflammation and are caused by defects …

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory
disease (AID) affecting mainly the ethnic groups originating from Mediterranean basin. The …

Autoinflammatory diseases are associated with abnormal activation of the innate immune
system, leading to clinical inflammation and high levels of acute-phase reactants. The first …